Bioinfo Solutions | Colorado | Projects & Publications

PUBLICATIONS

We handle and analyze all types of data: from human genetic information to industrial process readings. Our clients include large and small academic laboratories, medical device manufacturers, biotechnology companies and the public sector.

~~Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia.~~

Merrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD, Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, O'Shea C, Coldren C, Orlicky DJ, Lu X, Baron AE, Hickey G, Kennedy TC, Powell R, Heasley L, Bunn PA, Geraci M, Nemenoff RA. Cancer Res. 2018 Sep 1;78(17):4971-4983.

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~~The basophil proteome in chronic spontaneous urticaria distinguishes responders to omalizumab from non-responders.~~

Stitt JM, Dzieciatkowska M, Edwards MG, Hansen K, Hedlund G, Dreskin SC.

Clin Exp Allergy. 2018 Apr 19.

doi: 10.1111/cea.13149. [Epub ahead of print]

PMID:29671921

~~Lung Vascular Remodeling, Cardiac Hypertrophy, and Inflammatory Cytokines in SHIVnef-Infected Macaques.~~

Almodovar S, Swanson J, Giavedoni LD, Kanthaswamy S, Long CS, Voelkel NF, Edwards MG, Folkvord JM, Connick E, Westmoreland SV, Luciw PA, Flores SC.

Viral Immunol. 2018 Apr;31(3):206-222.

doi: 10.1089/vim.2017.0051. Epub 2017 Dec 19.

PMID:29256819

~~Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy.~~

Burchill MA, Roby JA, Crochet N, Wind-Rotolo M, Stone AE, Edwards MG, Dran RJ, Kriss MS, Gale M Jr, Rosen HR.

PLoS One. 2017 Oct 17;12(10):e0186213.

PMID: 29040318

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~~Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome.~~

Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU

PloS one. 2017; 12(2):e0172116.
PubMed [journal]PMID: 28196122 PMCID: PMC5308835

~~Free Fatty Acids Differentially Downregulate Chemokines in Liver Sinusoidal Endothelial Cells: Insights into Non-Alcoholic Fatty Liver Disease.~~

McMahan RH, Porsche CE, Edwards MG, Rosen HR

PloS one. 2016; 11(7):e0159217.
PubMed [journal]PMID: 27454769 PMCID: PMC4959750

~~Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation.~~

Bin L, Deng L, Yang H, Zhu L, Wang X, Edwards MG, Richers B, Leung DY

PloS one. 2016; 11(12):e0167392.
PubMed [journal]PMID: 27907090 PMCID: PMC5132327

PMC5132327

~~Correction: Free Fatty Acids Differentially Downregulate Chemokines in Liver Sinusoidal Endothelial Cells: Insights into Non-Alcoholic Fatty Liver Disease.~~

McMahan RH, Porsche CE, Edwards MG, Rosen HR

PloS one. 2016; 11(12):e0168301.
PubMed [journal]PMID: 27930747 PMCID: PMC5145219

~~Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer.~~

Bikkavilli RK, Avasarala S, Van Scoyk M, Arcaroli J, Brzezinski C, Zhang W, Edwards MG, Rathinam MK, Zhou T, Tauler J, Borowicz S, Lussier YA, Parr BA, Cool CD, Winn RA.

Oncogene. 2015; 34(42):5317-28. NIHMSID: NIHMS635677
PubMed [journal]PMID: 25728679 PMCID: PMC4558401

~~Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors.~~

Hensel J, Duex JE, Owens C, Dancik GM, Edwards MG, Frierson HF, Theodorescu D.

Molecular cancer research : MCR. 2015; 13(9):1306-15. NIHMSID: NIHMS700911
PubMed [journal]PMID: 26078295 PMCID: PMC4573363

~~Novel Role for γ-Catenin in the Regulation of Cancer Cell Migration via the Induction of Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1).~~

Sechler M, Borowicz S, Van Scoyk M, Avasarala S, Zerayesus S, Edwards MG, Kumar Karuppusamy Rathinam M, Zhao X, Wu PY, Tang K, Bikkavilli RK, Winn RA.

The Journal of biological chemistry. 2015; 290(25):15610-20.
PubMed [journal]PMID: 25925948 PMCID: PMC4505473

~~RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer.~~

Griner EM, Dancik GM, Costello JC, Owens C, Guin S, Edwards MG, Brautigan DL, Theodorescu D.

Molecular cancer research : MCR. 2015; 13(3):483-92. NIHMSID: NIHMS650278
PubMed [journal]PMID: 25516960 PMCID: PMC4369172

~~Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver.~~

Mitchell AM, Stone AE, Cheng L, Ballinger K, Edwards MG, Stoddard M, Li H, Golden-Mason L, Shaw GM, Khetani S, Rosen HR.

mBio. 2015; 6(2):e02510.
PubMed [journal]PMID: 25714713 PMCID: PMC4357998

~~Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication.~~

Giugliano S, Kriss M, Golden-Mason L, Dobrinskikh E, Stone AE, Soto-Gutierrez A, Mitchell A, Khetani SR, Yamane D, Stoddard M, Li H, Shaw GM, Edwards MG, Lemon SM, Gale M Jr, Shah VH, Rosen HR.

Gastroenterology. 2015; 148(2):392-402.e13. NIHMSID: NIHMS640344
PubMed [journal]PMID: 25447848 PMCID: PMC4765499

PMC4765499

~~Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum.~~

Bin L, Edwards MG, Heiser R, Streib JE, Richers B, Hall CF, Leung DY.

The Journal of allergy and clinical immunology. 2014; 134(4):848-55. NIHMSID: NIHMS615455
PubMed [journal]PMID: 25159465 PMCID: PMC4186924

~~Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer.~~

Nickerson ML, Dancik GM, Im KM, Edwards MG, Turan S, Brown J, Ruiz-Rodriguez C, Owens C, Costello JC, Guo G, Tsang SX, Li Y, Zhou Q, Cai Z, Moore LE, Lucia MS, Dean M, Theodorescu D.

Clinical cancer research : an official journal of the American Association for Cancer Research. 2014; 20(18):4935-48. NIHMSID: NIHMS615541
PubMed [journal]PMID: 25225064 PMCID: PMC4166537

~~FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies.~~

Wynes MW, Hinz TK, Gao D, Martini M, Marek LA, Ware KE, Edwards MG, Böhm D, Perner S, Helfrich BA, Dziadziuszko R, Jassem J, Wojtylak S, Sejda A, Gozgit JM, Bunn PA Jr, Camidge DR, Tan AC, Hirsch FR, Heasley LE.

Clinical cancer research : an official journal of the American Association for Cancer Research. 2014; 20(12):3299-309. NIHMSID: NIHMS589187
PubMed [journal]PMID: 24771645 PMCID: PMC4062100

~~Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions.~~

Nakachi I, Rice JL, Coldren CD, Edwards MG, Stearman RS, Glidewell SC, Varella-Garcia M, Franklin WA, Keith RL, Lewis MT, Gao B, Merrick DT, Miller YE, Geraci MW.

Cancer prevention research (Philadelphia, Pa.). 2014; 7(2):255-65. NIHMSID: NIHMS550808
PubMed [journal]PMID: 24346345 PMCID: PMC3926809

~~Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension.~~

Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM.

American journal of respiratory cell and molecular biology. 2013; 49(6):951-9.
PubMed [journal]PMID: 23815102 PMCID: PMC3931110

~~Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease.~~

Bahr TM, Hughes GJ, Armstrong M, Reisdorph R, Coldren CD, Edwards MG, Schnell C, Kedl R, LaFlamme DJ, Reisdorph N, Kechris KJ, Bowler RP.

American journal of respiratory cell and molecular biology. 2013; 49(2):316-23.
PubMed [journal]PMID: 23590301 PMCID: PMC3824029

~~hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression.~~

Avasarala S, Van Scoyk M, Wang J, Sechler M, Vandervest K, Brzezinski C, Weekes C, Edwards MG, Arcaroli J, Davis RE, Bikkavilli RK, Winn RA.

Biology open. 2013; 2(7):675-85.
PubMed [journal]PMID: 23862015 PMCID: PMC3711035

~~Role of IL-18 in second-hand smoke-induced emphysema.~~

Kratzer A, Salys J, Nold-Petry C, Cool C, Zamora M, Bowler R, Koczulla AR, Janciauskiene S, Edwards MG, Dinarello CA, Taraseviciene-Stewart L.

American journal of respiratory cell and molecular biology. 2013; 48(6):725-32.
PubMed [journal]PMID: 23392573 PMCID: PMC3727875

~~Need for rigor in design, reporting, and interpretation of transcriptomic biomarker studies.~~

Walter ND, Bemis L, Edwards M, Ovrutsky AR, Chan ED.

Journal of clinical microbiology. 2012; 50(12):4190-1; discussion 4192-3.
PubMed [journal]PMID: 23162111 PMCID: PMC3502969

~~Mitogen-activated protein kinase phosphatase-1 modulates regional effects of injurious mechanical ventilation in rodent lungs.~~

Park MS, He Q, Edwards MG, Sergew A, Riches DW, Albert RK, Douglas IS.

American journal of respiratory and critical care medicine. 2012; 186(1):72-81.
PubMed [journal]PMID: 22582160 PMCID: PMC3400991

~~Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription.~~

Clark DW, Phang T, Edwards MG, Geraci MW, Gillespie MN.

Free radical biology & medicine. 2012; 53(1):51-9. NIHMSID: NIHMS374561
PubMed [journal]PMID: 22583700 PMCID: PMC3377816

~~Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumors.~~

Michaelis KA, Knox AJ, Xu M, Kiseljak-Vassiliades K, Edwards MG, Geraci M, Kleinschmidt-DeMasters BK, Lillehei KO, Wierman ME.

Endocrinology. 2011; 152(10):3603-13.
PubMed [journal]PMID: 21810943 PMCID: PMC4714647

Increased cell surface Fas expression is necessary and sufficient to sensitize lung fibroblasts to Fas ligation-induced apoptosis: implications for fibroblast accumulation in idiopathic pulmonary fibrosis.

Wynes MW, Edelman BL, Kostyk AG, Edwards MG, Coldren C, Groshong SD, Cosgrove GP, Redente EF, Bamberg A, Brown KK, Reisdorph N, Keith RC, Frankel SK, Riches DW.

Journal of immunology (Baltimore, Md. : 1950). 2011; 187(1):527-37.
PubMed [journal]PMID: 21632719

~~Elevated DISC1 transcript levels in PBMCs during acute psychosis in patients with schizophrenia.~~

Olincy A, House R, Gao B, Recksiek P, Phang TL, Sullivan B, Hollis JP, Hopkins J, Shade T, Edwards MG, Vianzon R, Griffiths C, Ceilley J, Helfrich RW, Ritvo J, Weis E, Weiss D, Gault J.

Translational biomedicine. 2011; 2(1). NIHMSID: NIHMS338760
PubMed [journal]PMID: 22319686 PMCID: PMC3272882

~~Smoking reduces surfactant protein D and phospholipids in patients with and without chronic obstructive pulmonary disease.~~

Moré JM, Voelker DR, Silveira LJ, Edwards MG, Chan ED, Bowler RP.

BMC pulmonary medicine. 2010; 10:53.
PubMed [journal]PMID: 20973980 PMCID: PMC2987951

~~Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response.~~

Anderson RM, Barger JL, Edwards MG, Braun KH, O'Connor CE, Prolla TA, Weindruch R.

Aging cell. 2008; 7(1):101-11.
PubMed [journal]PMID: 18031569 PMCID: PMC2253697

~~Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program.~~

Edwards MG, Anderson RM, Yuan M, Kendziorski CM, Weindruch R, Prolla TA.

BMC genomics. 2007; 8:80.
PubMed [journal]PMID: 17381838 PMCID: PMC1847444

~~Impairment of the transcriptional responses to oxidative stress in the heart of aged C57BL/6 mice.~~

Edwards MG, Sarkar D, Klopp R, Morrow JD, Weindruch R, Prolla TA.

Annals of the New York Academy of Sciences. 2004; 1019:85-95.
PubMed [journal]PMID: 15246999

~~Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart.~~

Edwards MG, Sarkar D, Klopp R, Morrow JD, Weindruch R, Prolla TA.

Physiological genomics. 2003; 13(2):119-27.
PubMed [journal]PMID: 12595580

~~Attenuated transcriptional responses to oxidative stress in the aged rat brain.~~

Tong L, Toliver-Kinsky T, Edwards M, Rassin DK, Werrbach-Perez K, Perez-Polo JR.

Journal of neuroscience research. 2002; 70(3):318-26.
PubMed [journal]PMID: 12391591

~~Use of an antineoepitope antibody for identification of type-II collagen degradation in equine articular cartilage.~~

Billinghurst RC, Buxton EM, Edwards MG, McGraw MS, McIlwraith CW.

American journal of veterinary research. 2001; 62(7):1031-9.
PubMed [journal]PMID: 11453476

~~APE/Ref-1 responses to ischemia in rat brain.~~

Edwards M, Kent TA, Rea HC, Wei J, Quast M, Izumi T, Mitra S, Perez-Polo JR.

Neuroreport. 1998; 9(18):4015-8.
PubMed [journal]PMID: 9926839

~~APE/Ref-1 responses to oxidative stress in aged rats.~~

Edwards M, Rassin DK, Izumi T, Mitra S, Perez-Polo JR.

Journal of neuroscience research. 1998; 54(5):635-8.
PubMed [journal]PMID: 9843154

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